Russell Martin’s side will take on the Black Cats from 3pm despite a blaze in the industrial estate opposite the stadium this week.
Southampton’s match against Preston North End on Wednesday was postponed just hours ahead of kick-off.
A Saints statement said: “We’re really looking forward to welcoming you back to St Mary’s on Saturday for our game against Sunderland.
“We’ve been working really hard with the local authorities and emergency services to make sure the game can go ahead, however, you will notice some small changes around the stadium as a result of the fire in the nearby industrial units.
“Due to its close proximity to the site of the fire, the family zone will be closed, but you’re welcome to join in the fun of the activations in the Kingsland area.
“Whilst the stadium store remains open, offering a huge 50% sale on this season’s kit and training wear, there will be some areas in the South Car Park that will be closed, so please refer to signage in that area to keep you safe and away from any impacted areas.
“We’ve also been advised that normal matchday road closures will be in place, so please ensure you leave enough time to arrive and enter the stadium safely.
“We want to thank everyone who’s worked hard to get the stadium ready for tomorrow, and to all our fans who’ve offered their support. See you tomorrow!”
