Emma Hayes indicated the need to make changes in the games ahead, following naming an unchanged side for the win in Amsterdam during the week, and she has been true to her word.
There are three switches from the side that began against Ajax on Tuesday.
Ashley Lawrence replaces Eve Perisset in defence and in midfield, Jelana Cankovic comes in for Erin Cuthbert.
Aggie Beever-Jones is the other player brought into the side for this WSL encounter in east London. Guro Reiten makes way.
Lauren James is retained in attack and Tuesday’s other goalscorer, Sjoeke Nusken, also starts.
Niamh Charles continues as a league ever-present this season and is captain of the side.
Nathalie Bjorn has recovered from the calf injury that kept her out of two games and is named among the substitutes. Mayra Ramirez is back after missing three games.
West Ham makes two changes from their defeat at Liverpool last time out.
Chelsea Hampton; Lawrence, Carter, Buchanan, Charles (c), Cankovic, Leupolz, Rytting Kaneryd, Nusken, Beever-Jones, James
Subs Musovic, Perisset, Bjorn, Cuthbert, Ingle, Reiten, Kirby, Macario, Ramirez
West Ham Arnold (c); Zadorsky, Tysiak, Denton, Smith, Gorry, Hayashi, Shimizu, Ziu, Asseyi, Ueki
Subs Walsh, Cooke, Ademiluyi, Cissoko, Bergman Lundin, O’Hanlon, Snerle, Harries
Referee Megan Wilson
