Everton will be given no time to lick their wounds after surrendering another 2-0 lead on Saturday, as they are thrown straight back into action on Tuesday night.
Moving from the Premier League back into the Carabao Cup, their easy win over Doncaster Rovers last month secured their name in the hat and saw them earn a home draw against Southampton.
Their sole victory of the entire campaign has come in this competition, and it could now be their second should they overcome a Saints side in just as bad form as they are.
However, after yet another damaging and demoralising defeat, spirits at Goodison Park might just be at an all-time low.
Sean Dyche has to do something special to ensure that the nervousness of their poor start does not translate onto the players, thus making this team selection imperative.
Predicted Everton XI for Carabao Cup match vs Southampton
After yet another defeat, the boss is expected to ring in the changes, with seven predicted after the Aston Villa match on Saturday.
The first could well come in goal, especially after one report suggested that Dyche is unhappy with Jordan Pickford and could well look to sell him soon.
Joao Virginia could therefore take his place, sitting behind a backline altered where possible.
There will arguably be no better time to give Jake O’Brien his first chance to face Premier League opposition without the stakes involved with league football, so he has to partner James Tarkowski, seeing Ashley Young move to left-back to cover the ill Vitaliy Mykolenko.
That will leave a frustrating vacancy at right-back, which James Garner will simply have to fill.
Moving into midfield and Tim Iroegbunam is unlikely to lose his spot, but the 34-year-old Idrissa Gana Gueye probably should make way to see if Orel Mangala is up to match fitness.
If the £50k-a-week loanee impresses, he could easily cement a starting spot going forward.
